Analytical Data
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基因名
ACD
- Application
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别名
ACD；PIP1；PTOP；TINT1；Adrenocortical dysplasia Protein homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96AP0
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表达区间
1-458aa
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氨基酸序列
MAGSGRLVLRPWIRELILGSETPSSPRAGQLLEVLQDAEAAVAGPSHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWEEKEFGFRGTEGRLLLLQDCGVHVQVAEGGAPAEFYLQVDRFSLLPTEQPRLRVPGCNQDLDVQKKLYDCLEEHLSESTSSNAGLSLSQLLDEMREDQEHQGALVCLAESCLTLEGPCTAPPVTHWAASRCKATGEAVYTVPSSMLCISENDQLILSSLGPCQRTQGPELPPPDPALQDLSLTLIASPPSSPSSSGTPALPGHMSSEESGTSISLLPALSLAAPDPGQRSSSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPRSHVPSPHQALVTRPQKPSLEFKEFVGLPCKNRPPFPRTGATRGAQEPCSVWEPPKRHRDGSAFQYEYEPPCTSLCARVQAVRLPPQLMAWALHFLMDAQPGSEPTPM
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACD (Activation-induced cytidine deaminase) is a key enzyme in the process of somatic hypermutation and class switch recombination, critical for the generation of diverse antibody responses in B cells. Research into ACD has gained significant momentum due to its role in immune system fidelity, as its activity can lead to both beneficial antibody diversification and pathogenic mutations that contribute to B cell malignancies, including lymphomas and leukemias. Understanding the mechanism of ACD action, particularly its regulation and interactions with other cellular factors, is essential for elucidating its dual role in immune function and oncogenesis. Additionally, the potential therapeutic implications of modulating ACD activity highlight its importance; aberrant ACD function has been linked to autoimmune diseases and cancers, making it a target for innovative treatments. Recent studies employing advanced genomic, proteomic, and biochemical techniques aim to uncover the nuances of ACD's function and regulation, paving the way for future research in immunology and oncology. As the field progresses, addressing the challenges of specificity and off-target effects in potential ACD-targeting therapies will be crucial to harnessing its potential benefits while minimizing risks.
