Analytical Data
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Gene name
CAPG
- Application
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Alternative Names
CAPG；AFCP；MCP；Macrophage-capping Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40121
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Expression Region
1-348aa
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AA Sequence
MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDWK
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Molecular Weight
65.5kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAPG (Cytoskeleton-associated protein G) is an actin-binding protein that plays a critical role in regulating cellular processes such as motility, morphology, and division. Research into CAPG has gained momentum due to its involvement in various diseases, including cancer and autoimmune disorders. It is known to interact with other cytoskeletal elements, influencing actin dynamics and cellular architecture. Understanding the mechanisms by which CAPG regulates these processes is vital for potential therapeutic interventions. Current studies are focusing on the structural characterization of CAPG through recombinant protein expression to elucidate its functional domains and binding partners. By producing CAPG as a recombinant protein, researchers aim to investigate its biochemical properties and role in cellular signaling pathways, thereby uncovering its contributions to disease mechanisms. This research not only enhances our understanding of CAPG's functions in normal physiology but also paves the way for developing targeted therapies that could mitigate its pathological effects in various diseases. Through a combination of biochemical assays, structural biology techniques, and in vivo studies, the characterization of CAPG holds the promise of revealing novel insights into the intricacies of cytoskeletal regulation and its implications in health and disease.
