Cat: PA1000-388DB

Recombinant Human CA11 Protein,His

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Analytical Data

  • Gene name

    CA11

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CA11;AMP18;CA11;Gastrokine-1

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    O75493

  • Expression Region

    24-328aa

  • AA Sequence

    HIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN FSAASRGPNG LAILSLFVNV ASTSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR GNRDPRHPER RCRGPNYRLH VDGVPHGR

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

CA11, or carbonic anhydrase 11, is a member of the carbonic anhydrase enzyme family, which plays a crucial role in catalyzing the reversible conversion of carbon dioxide and water to bicarbonate and protons. This enzyme is predominantly expressed in the brain and certain other tissues, suggesting its significant role in physiological functions such as pH regulation and CO2 transport. Research on CA11 has garnered interest due to its association with various physiological and pathological processes, including neuronal signaling, acid-base balance, and potential implications in diseases such as epilepsy and neurodegenerative disorders. The recombinant form of CA11 is often studied to understand its enzymatic properties, structural dynamics, and potential applications in biotechnology and medicine. By producing CA11 as a recombinant protein, researchers can investigate its kinetic behavior, develop inhibitors for therapeutic strategies, and explore its use in biosensing applications. Furthermore, understanding CA11's structural features through techniques like X-ray crystallography and nuclear magnetic resonance (NMR) can provide insights into its function and regulation. Overall, the study of recombinant CA11 is vital for elucidating its biological roles and exploring its therapeutic potential.

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