Analytical Data
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Gene name
MSRB3
- Application
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Alternative Names
Deafness, Autosomal Recessive 74; DFNB74; FLJ36866; Methionine R sulfoxide reductase B mitochondrial; Methionine sulfoxide reductase B3; Methionine-R-sulfoxide reductase B3; MsrB3; MSRB3_HUMAN
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IXL7
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Expression Region
1-185aa
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MSRB3 (Methionine Sulfoxide Reductase B3) is an essential enzyme that plays a crucial role in cellular redox homeostasis by repairing oxidatively damaged proteins through the reduction of methionine sulfoxide back to methionine. This enzymatic activity is vital for maintaining protein functionality, particularly under oxidative stress conditions, which can occur during various physiological processes and pathological states, including aging, neurodegeneration, and cancer. The study of MSRB3 has gained significant interest due to its potential implications in enhancing cellular resilience against oxidative damage, as well as its involvement in the regulation of various signaling pathways. Furthermore, the enzyme is known to interact with other cellular antioxidants, thereby influencing overall antioxidant defense systems. Research into MSRB3 is also revealing its roles beyond mere antioxidant activity, including involvement in cellular signaling and transcriptional regulation. Given the increasing prevalence of oxidative stress-related diseases, understanding the structure, function, and regulatory mechanisms of MSRB3 is not only pivotal for advancing basic biological knowledge but also for exploring therapeutic strategies aimed at modulating its activity to mitigate oxidative damage and improve cellular health. Consequently, MSRB3 represents a promising target for drug development and has the potential to offer insights into new therapeutic approaches for diseases linked to oxidative stress and protein misfolding.
