Analytical Data
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基因名
ADORA2a
- Application
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别名
ADORA2a；ADORA2；Adenosine receptor A2a
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29274
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表达区间
1-412aa
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氨基酸序列
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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分子量
44.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the ADORA2A recombinant protein is grounded in its significant role in the human adenosine A2A receptor (ADORA2A), which is a pivotal G protein-coupled receptor involved in a variety of physiological processes, including modulation of neurotransmitter release, vasodilation, and immune responses. This receptor is of particular interest in the fields of neuroscience and pharmacology due to its involvement in neurodegenerative disorders, mood regulation, and cardiovascular diseases. Abnormal ADORA2A signaling has been implicated in conditions such as Parkinson's disease, schizophrenia, and anxiety disorders, making it a potential therapeutic target. The recombinant production of ADORA2A not only allows for detailed structural and functional studies but also aids in high-throughput screening for small molecules that may act as agonists or antagonists, potentially leading to novel treatments. Furthermore, understanding the intricate signaling pathways mediated by ADORA2A through its recombinant form can provide insights into the receptor's role in various pathophysiological contexts. Overall, research on ADORA2A recombinant protein is crucial for advancing our understanding of adenosine signaling and its therapeutic implications.
