Analytical Data
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基因名
ATP5C1
- Application
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别名
ATP5C1；ATP5C；ATP5C1；ATP5CL1；ATP synthase subunit gamma. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36542
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表达区间
26-298aa
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氨基酸序列
ATLKD ITRRLKSIKN IQKITKSMKM VAAAKYARAE RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR GLCGAIHSSI AKQMKSEVAT LTAAGKEVML VGIGDKIRGI LYRTHSDQFL VAFKEVGRKP PTFGDASVIA LELLNSGYEF DEGSIIFNKF RSVISYKTEE KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY SLKESTTSEQ SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP5C1, a subunit of ATP synthase, plays a crucial role in cellular energy metabolism by facilitating ATP production in mitochondria. The gene encoding ATP5C1 has garnered attention due to its involvement in various metabolic disorders and potential implications in cancer biology. Research indicates that dysregulation of ATP5C1 can impact mitochondrial function and energy homeostasis, contributing to the pathology of diseases such as neurodegenerative disorders and certain types of cancer. Furthermore, ATP5C1's expression levels have been linked to the aggressiveness of tumors, positioning it as a potential biomarker for cancer prognosis. Studies on recombinant ATP5C1 proteins aim to elucidate its structural and functional properties, which can provide insights into its role in ATP synthesis and reveal potential therapeutic targets. The recombinant expression of ATP5C1 allows for a detailed investigation of its enzymatic activity, interaction with other mitochondrial components, and regulatory mechanisms. Understanding these aspects could pave the way for novel strategies to manipulate energy metabolism in disease contexts, making ATP5C1 a significant focus of ongoing biochemical research.
