Analytical Data
-
基因名
ATOH1
- Application
-
别名
ATOH1；ATH1；BHLHA14；Transcription factor ATOH1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q92858
-
表达区间
1-354aa
-
氨基酸序列
MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
-
分子量
40.2kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATOH1 (Atonal homolog 1) is a critical transcription factor involved in the development of various cell types, particularly in the nervous system and the inner ear, where it plays a pivotal role in the differentiation of hair cells. The study of ATOH1 recombinant protein has garnered attention due to its potential applications in regenerative medicine, especially for hearing loss caused by sensory cell damage. Research indicates that ATOH1 activation can promote the regeneration of hair cells in the cochlea, presenting a promising therapeutic strategy for hearing restoration. By producing ATOH1 as a recombinant protein, researchers can investigate its functional properties, interactions, and mechanisms of action in cellular environments. This has significant implications for understanding its role in auditory system development and offers insights for developing gene therapy approaches. Furthermore, elucidating the structure-function relationship of ATOH1 through recombinant protein studies can contribute to the identification of small molecules or peptides that can mimic its activity, enhancing the prospects for hearing recovery in clinical settings. As research progresses, the exploration of ATOH1 recombinant protein not only holds promise for innovative treatment options but also enhances our broader understanding of transcriptional regulation in cellular differentiation.
