Analytical Data
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基因名
CCND1
- Application
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别名
CCND1；BCL1；PRAD1；G1/S-specific cyclin-D1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24385
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表达区间
1-295aa
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氨基酸序列
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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分子量
81.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclin D1 (CCND1) is a crucial regulator of cell cycle progression, particularly in the transition from the G1 phase to the S phase. The aberrant expression of CCND1 has been closely associated with various cancers, including breast, lung, and colorectal cancers, making it a significant focus of cancer research. Overexpression of CCND1 can lead to uncontrolled cell proliferation and contribute to tumorigenesis, while mutations in the CCND1 gene can impact its function. In recent years, the development of recombinant CCND1 protein has facilitated the investigation of its biochemical properties and interactions with other cell cycle regulators. This research has not only provided insights into the mechanisms of cell cycle control but also highlighted CCND1 as a potential therapeutic target. By utilizing techniques such as protein expression in bacterial systems and purification, scientists are able to produce large quantities of CCND1 for functional studies. These studies are essential for understanding how CCND1's dysregulation contributes to cancer pathology and for exploring new treatment strategies that could inhibit its function in cancer cells. The ongoing research into CCND1 and its role in the cell cycle underscores its importance as both a biomarker for cancer progression and a potential target for novel therapeutic interventions.
