Analytical Data
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Gene name
CCND1
- Application
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Alternative Names
CCND1；BCL1；PRAD1；G1/S-specific cyclin-D1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P24385
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Expression Region
1-295aa
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AA Sequence
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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Molecular Weight
81.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclin D1 (CCND1) is a crucial regulator of cell cycle progression, particularly in the transition from the G1 phase to the S phase. The aberrant expression of CCND1 has been closely associated with various cancers, including breast, lung, and colorectal cancers, making it a significant focus of cancer research. Overexpression of CCND1 can lead to uncontrolled cell proliferation and contribute to tumorigenesis, while mutations in the CCND1 gene can impact its function. In recent years, the development of recombinant CCND1 protein has facilitated the investigation of its biochemical properties and interactions with other cell cycle regulators. This research has not only provided insights into the mechanisms of cell cycle control but also highlighted CCND1 as a potential therapeutic target. By utilizing techniques such as protein expression in bacterial systems and purification, scientists are able to produce large quantities of CCND1 for functional studies. These studies are essential for understanding how CCND1's dysregulation contributes to cancer pathology and for exploring new treatment strategies that could inhibit its function in cancer cells. The ongoing research into CCND1 and its role in the cell cycle underscores its importance as both a biomarker for cancer progression and a potential target for novel therapeutic interventions.
