Analytical Data
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基因名
AS3MT
- Application
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别名
AS3MT；CYT19；Arsenite methyltransferase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HBK9
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表达区间
1-375aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMAALRD AEIQKDVQTY YGQVLKRSAD LQTNGCVTTA RPVPKHIREA LQNVHEEVAL RYYGCGLVIP EHLENCWILD LGSGSGRDCY VLSQLVGEKG HVTGIDMTKG QVEVAEKYLD YHMEKYGFQA SNVTFIHGYI EKLGEAGIKN ESHDIVVSNC VINLVPDKQQ VLQEAYRVLK HGGELYFSDV YTSLELPEEI RTHKVLWGEC LGGALYWKEL AVLAQKIGFC PPRLVTANLI TIQNKELERV IGDCRFVSAT FRLFKHSKTG PTKRCQVIYN GGITGHEKEL MFDANFTFKE GEIVEVDEET AAILKNSRFA QDFLIRPIGE KLPTSGGCSA LELKDIITDP FKLAEESDSM KSRCVPDAAG GCCGTKKSC
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分子量
44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Protein Description
AS3MT (Arsenic (+3 oxidation state) Methyltransferase) is an enzyme critically involved in the metabolism of arsenic, a well-known environmental contaminant and toxic metalloid. The human AS3MT gene encodes a protein that catalyzes the methylation of inorganic arsenic, thereby facilitating its detoxification and excretion. This enzyme plays a pivotal role in the biotransformation process, converting arsenic into less toxic forms such as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Research on AS3MT is essential not only for understanding individual susceptibility to arsenic toxicity, which can lead to serious health issues including cancer, skin lesions, and cardiovascular diseases, but also for developing effective therapies and interventions for arsenic exposure. Genetic polymorphisms in the AS3MT gene have been linked to variations in arsenic metabolism among individuals, highlighting the importance of studying this enzyme in diverse populations. Moreover, AS3MT is also of interest in the context of environmental science, as it can influence the bioaccumulation of arsenic in food chains. Ongoing studies aim to elucidate the mechanistic pathways of AS3MT function, investigate its regulation, and explore potential therapeutic targets for minimizing arsenic-related health risks. Understanding the complexities of AS3MT's role in arsenic metabolism could provide critical insights into public health strategies aimed at mitigating the impact of arsenic exposure in affected communities. As arsenic contamination remains a significant global concern, research on AS3MT continues to be a focal point in both toxicology and environmental health disciplines, necessitating further investigation into its biochemical mechanisms and genetic variations.
