Recombinant Escherichia coli cdtB Protein ，His & SUMO

CdtB, a component of the cytolethal distending toxin (CDT) produced by certain pathogenic bacteria, has garnered significant attention in the field of microbiology and immunology due to its role in bacterial pathogenesis and its potential as a therapeutic target. This toxin is known to induce cell cycle arrest and promote apoptosis in host cells, which contributes to the virulence of bacteria such as *Campylobacter jejuni*, *Escherichia coli*, and *Helicobacter pylori*. Research into CdtB has revealed its mechanism of action, which involves the targeting of host cell DNA and disrupting cellular functions. Understanding the structure and function of CdtB is crucial for developing strategies to inhibit its activity, paving the way for novel therapeutic approaches against CDT-producing pathogens. Moreover, CdtB has been explored as a vaccine candidate, due to its ability to elicit immune responses, thus highlighting its dual role both as a virulence factor and a potential tool in immunotherapy. As studies continue to unravel the complexities of CdtB interactions with the host immune system, the insights gained may lead to advancements in vaccines and treatments for infectious diseases caused by CDT-producing bacteria, underscoring the importance of this research in combating bacterial infections effectively.