Analytical Data
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基因名
ARG1
- Application
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别名
ARG1；ARF1GAP；ADP-ribosylation factor GTPase-activating Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05089
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表达区间
1-322aa
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氨基酸序列
MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT LACFGLAREG NHKPIDYLNP PK
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分子量
36 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Arginase 1 (ARG1) is an important enzyme involved in the urea cycle, catalyzing the hydrolysis of arginine to produce urea and ornithine. Its role extends beyond merely metabolic processes; it has been implicated in various physiological and pathological conditions, including immune response regulation and tissue remodeling. In particular, ARG1 is expressed in macrophages and is associated with the M2 phenotype, which is linked to anti-inflammatory responses and tissue repair. Research has shown that elevated levels of ARG1 are often found in various diseases, including cancer and chronic inflammatory conditions, making it a potential biomarker and therapeutic target. Consequently, recombinant ARG1 proteins have been developed to study their functional implications in these contexts. These recombinant proteins enable researchers to explore the biochemical pathways involving arginine metabolism and to assess their influence on immune modulation and tumor microenvironments. Furthermore, understanding the structural and functional characteristics of recombinant ARG1 may provide insights into its regulatory mechanisms and potential applications in targeted therapies. The ongoing investigation of ARG1 not only aids in elucidating its biological significance but also assists in the development of innovative strategies for treating diseases associated with dysregulated arginine metabolism.
