Analytical Data
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Gene name
ARX
- Application
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Alternative Names
ARX；Homeobox Protein ARX
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96QS3
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Expression Region
1-562aa
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AA Sequence
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLTSRADP EKAVQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAAATATAG PRGEAPPPPP PTARPGERPD GAGAAAAAAA AAAAAWDTLK ISQAPQVSIS RSKSYRENGA PFVPPPPALD ELGGPGGVTH PEERLGVAGG PGSAPAAGGG TGTEDDEEEL LEDEEDEDEE EELLEDDEEE LLEDDARALL KEPRRCPVAA TGAVAAAAAA AVATEGGELS PKEELLLHPE DAEGKDGEDS VCLSAGSDSE EGLLKRKQRR YRTTFTSYQL EELERAFQKT HYPDVFTREE LAMRLDLTEA RVQVWFQNRR AKWRKREKAG AQTHPPGLPF PGPLSATHPL SPYLDASPFP PHHPALDSAW TAAAAAAAAA FPSLPPPPGS ASLPPSGAPL GLSTFLGAAV FRHPAFISPA FGRLFSTMAP LTSASTAAAL LRQPTPAVEG AVASGALADP ATAAADRRAS SIAALRLKAK EHAAQLTQLN ILPGTSTGKE VC
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ARX (Aristaless Related Homeobox) is a transcription factor that plays a crucial role in the development of the central nervous system, particularly in influencing the differentiation and function of neuronal subtypes. Mutations in the ARX gene have been linked to a range of neurological disorders, including intellectual disability, epilepsy, and various forms of encephalopathy. Recent studies have highlighted its importance in regulating gene expression during neurogenesis and in maintaining the balance between neuronal and glial cell populations. Research into ARX reconstituted proteins aims to elucidate its functional mechanisms by facilitating the study of its interactions with DNA and other protein partners. By creating recombinant ARX proteins, scientists can investigate how specific mutations affect its structural stability, DNA-binding affinity, and transcriptional activity. Furthermore, understanding the implications of ARX in neural development could provide insights into potential therapeutic interventions for related disorders. Given its critical role in brain development, the study of ARX and its reconstituted proteins is not only significant for fundamental neuroscience but also for developing strategies to address the consequences of ARX-related pathologies. This research holds promise for advancing our knowledge of neuronal development and for paving the way toward targeted treatments for genetic and developmental neurological disorders.
