Analytical Data
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Gene name
pks13
- Application
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Species
Mycobacterium tuberculosis
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Source
E. coli
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Tag
N- His-MBP
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
I6X8D2
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Expression Region
1451-1733aa
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Molecular Weight
75.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PKS13 (polyketide synthase 13) is an essential enzyme that plays a critical role in the biosynthesis of mycobacterial cell wall components, particularly in the production of phenolic glycolipids. This protein is part of the polyketide synthase family, which is involved in the synthesis of a variety of biologically active compounds. Research into PKS13 has gained significant attention due to its potential implications in understanding the pathogenicity of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB). Given the rising incidence of multidrug-resistant TB strains, elucidating the structure and function of PKS13 could provide insights into novel therapeutic targets. The study of recombinant PKS13 protein allows researchers to investigate its enzymatic mechanisms, substrate specificity, and regulation. Furthermore, exploring the interactions between PKS13 and other cellular components can lead to a deeper comprehension of mycobacterial metabolism and survival strategies. The recombinant expression of PKS13 in heterologous systems also facilitates high-throughput screening of inhibitors that may disrupt its function, paving the way for new anti-TB drugs. Overall, the investigation of PKS13 is crucial not only for the advancement of basic microbiological knowledge but also for the development of innovative approaches to combat one of the world's most persistent infectious diseases.
