Analytical Data
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基因名
SLC39A11
- Application
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别名
(Solute carrier family 39 member 11)(Zrt- and Irt-like protein 11)(ZIP-11)
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种属
Human
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表达系统
E. coli
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标签
N- His-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N1S5
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表达区间
93-193aa
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分子量
42.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC39A11, also known as ZIP11, is a member of the Zrt/Irt-like protein (ZIP) family, which plays a crucial role in metal ion transport across cellular membranes. This protein is implicated in the uptake of zinc, an essential micronutrient involved in various biological processes, including enzyme function, antioxidant defense, and cellular signaling. Dysregulation of SLC39A11 has been associated with several pathophysiological conditions, including neurodegenerative diseases and cancer, highlighting its potential as a therapeutic target. Recent studies have focused on the structural and functional characterization of SLC39A11, particularly through the production of recombinant protein. By expressing and purifying SLC39A11 in heterologous systems, researchers aim to elucidate the mechanisms by which this transporter mediates zinc transport and to identify its regulatory elements. Understanding the biophysical properties of the recombinant protein can provide insights into its interaction with zinc and other metal ions, as well as its role in cellular homeostasis. Furthermore, this research could pave the way for developing novel interventions to modulate the activity of SLC39A11 in diseases associated with dysregulated zinc metabolism. Overall, the study of SLC39A11 recombinant protein represents an important step toward unraveling the complexities of zinc transport and its implications in human health.
