Analytical Data
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Gene name
DAZL
- Application
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Alternative Names
(DAZ homolog)(DAZ-like autosomal)(Deleted in azoospermia-like 1)(SPGY-like-autosomal)
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Species
Human
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Source
E. coli
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Tag
N- His-GST & C- V5-Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92904
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Expression Region
130-250aa
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Molecular Weight
50.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DAZL (Deleted in Azoospermia-Like) is a crucial RNA-binding protein that primarily plays a significant role in germ cell development and gametogenesis. Structurally similar to the DAZ protein family, DAZL is characterized by its presence in both male and female germ cells, supporting the regulation of mRNA during oogenesis and spermatogenesis. Research on DAZL has gained momentum due to its implications in fertility; mutations or dysregulation of DAZL expression can lead to disorders in gamete production and contribute to infertility in both genders. Recent studies have focused on understanding the molecular mechanisms through which DAZL influences mRNA stability and translation, including its interactions with thousands of target mRNAs identified via high-throughput sequencing techniques. Additionally, the impact of environmental factors and epigenetic modifications on DAZL function has opened new avenues for exploring the environmental influences on reproductive health. Given the rising concerns surrounding infertility and the need for effective therapeutic strategies, investigating DAZL's role in germ cell biology may provide valuable insights into potential interventions. Thus, research on DAZL not only furthers our understanding of reproductive biology but also emphasizes its potential as a biomarker for fertility assessments and targets for novel fertility treatments.
