Analytical Data
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Gene name
CD163L1
- Application
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Alternative Names
(CD163 antigen-like 1)(CD antigen CD163b)
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NR16
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Expression Region
48-469aa
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Molecular Weight
54.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD163L1, a member of the scavenger receptor cysteine-rich (SRCR) superfamily, is primarily expressed on the surface of macrophages and plays a significant role in the immune system. It is involved in the clearance of hemoglobin-haptoglobin complexes and modulates inflammatory responses. Research on CD163L1 has gained traction due to its potential role in various diseases, including cancer and autoimmune disorders. This receptor's ability to mediate immune tolerance and its involvement in tissue remodeling make it a critical target for therapeutic interventions. The recombinant protein of CD163L1 has garnered attention for its potential applications in diagnostic and therapeutic contexts, as it may serve as a biomarker for certain diseases and as a target for monoclonal antibody therapies. Studies have shown that CD163L1 interacts with various ligands, influencing macrophage polarization and function, which further highlights its importance in maintaining homeostasis within the immune environment. Understanding the structure-function relationship of the recombinant CD163L1 protein could pave the way for novel approaches in immunotherapy, emphasizing the need for comprehensive research into its biological functions and mechanisms of action. Overall, the investigation into CD163L1 recombinant protein not only provides insights into its role in immune regulation but also opens avenues for innovative therapeutic strategies targeting inflammatory and malignant conditions.
