Analytical Data
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Gene name
SAP
- Application
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Alternative Names
SAP；GLBA；SAP1；Prosaposin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60880-1
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Expression Region
1-128aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SAP (Spleen-Associated Protein) recombinant proteins have garnered significant attention in biomedical research due to their pivotal roles in cellular processes and immune responses. As a key component of the immune system, SAP is involved in the regulation of germinal center formation, antibody production, and the maintenance of memory B cells. Its multifunctional nature allows it to interact with various ligands and molecules, influencing both innate and adaptive immune responses. Research efforts have focused on the production of SAP recombinant proteins to further understand their biological functions and mechanisms of action. Advanced techniques in molecular biology and protein engineering have enabled the generation of these proteins in substantial quantities and with high purity, facilitating in vitro and in vivo studies. Investigations into SAP recombinant proteins aim to elucidate their therapeutic potential in various diseases, including autoimmune disorders and malignancies, where the modulation of SAP function could offer innovative treatment strategies. Moreover, understanding the structural biology of SAP can aid in the design of specific inhibitors or modulators that could fine-tune its activity, offering new avenues for drug development. Overall, the study of SAP recombinant proteins is paving the way for novel insights into immune regulation and potential therapeutic interventions.
