Analytical Data
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基因名
SGK2
- Application
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别名
SGK2；Serine/threonine-Protein kinase Sgk2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HBY8
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表达区间
1-427aa
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氨基酸序列
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVL LAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLR YSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEY LAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQP LQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASS AFLGFSYAPEDDDILDC
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分子量
71 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SGK2 (Serum/glucocorticoid-regulated kinase 2) is a member of the AGC kinase family, which plays a crucial role in various cellular processes, including cell survival, proliferation, and stress response. It is particularly implicated in the regulation of ion transport and metabolic pathways, making it a significant focal point in studies related to cardiovascular diseases, cancer, and diabetes. The interest in SGK2 has surged due to its potential as a therapeutic target and biomarker. Understanding SGK2's molecular mechanisms, interactions, and regulatory pathways requires the generation of recombinant SGK2 proteins for in vitro analysis and functional studies. Such research aims to elucidate the kinase's structure-function relationship and its role in disease progression, which could pave the way for the development of novel therapeutic strategies. Recent advances in protein expression systems and purification techniques have facilitated the production of high-purity SGK2, allowing researchers to investigate its enzymatic activity, phosphorylation targets, and involvement in signaling cascades. Given the complexity of SGK2's regulatory network, ongoing studies are essential to clarify its biological significance and therapeutic potential, particularly in the context of disorders where SGK2 dysregulation is observed. These investigations not only enhance our understanding of SGK2 but also contribute to the broader field of kinase research and its implications in human health.
