Analytical Data
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基因名
ALDH6A1
- Application
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别名
ALDH6A1；MMSDH；Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating]. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51647
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表达区间
34-535aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSSSSVPTV KLFIGGKFVE SKSDKWIDIH NPATNEVIGR VPQATKAEMD AAIASCKRAF PAWADTSVLS RQQVLLRYQQ LIKENLKEIA KLITLEQGKT LADAEGDVFR GLQVVEHACS VTSLMMGETM PSITKDMDLY SYRLPLGVCA GIAPFNFPAM IPLWMFPMAM VCGNTFLMKP SERVPGATML LAKLLQDSGA PDGTLNIIHG QHEAVNFICD HPDIKAISFV GSNKAGEYIF ERGSRHGKRV QANMGAKNHG VVMPDANKEN TLNQLVGAAF GAAGQRCMAL STAVLVGEAK KWLPELVEHA KNLRVNAGDQ PGADLGPLIT PQAKERVCNL IDSGTKEGAS ILLDGRKIKV KGYENGNFVG PTIISNVKPN MTCYKEEIFG PVLVVLETET LDEAIQIVNN NPYGNGTAIF TTNGATARKY AHLVDVGQVG VNVPIPVPLP MFSFTGSRSS FRGDTNFYGK QGIQFYTQLK TITSQWKEED ATLSSPAVVM PTMGR
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分子量
57 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ALDH6A1, a member of the aldehyde dehydrogenase gene family, plays a critical role in the metabolism of fatty acids and neurotransmitters by catalyzing the oxidation of aldehydes to their corresponding carboxylic acids. Mutations in the ALDH6A1 gene have been associated with various metabolic disorders, including a rare autosomal recessive disorder known as ALDH6A1 deficiency, which leads to neurological impairments and developmental delays. As a result, research into the recombinant protein of ALDH6A1 has gained significant attention, primarily to better understand its structural and functional characteristics and to explore potential therapeutic interventions. The production of recombinant ALDH6A1 enables detailed biochemical studies, such as enzyme kinetics, substrate specificity, and the effects of pathogenic mutations. Moreover, understanding the enzyme's three-dimensional structure may provide insights into its catalytic mechanism and interactions with other biomolecules. This research is not only crucial for elucidating the biochemical pathways affected by ALDH6A1 dysfunction but also highlights the potential for developing enzyme replacement therapies or other molecular therapies targeted at restoring normal function in affected individuals. Overall, the study of ALDH6A1 recombinant protein opens avenues for advancing our knowledge of metabolic disorders and improving the quality of life for patients suffering from ALDH6A1-related conditions.
