Analytical Data
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Gene name
UTY
- Application
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Alternative Names
(Ubiquitously transcribed TPR protein on the Y chromosome)(Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein)([histone H3]-trimethyl-L-lysine(27) demethylase UTY)
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Species
Chimpanzee
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6B4Z3
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Expression Region
209-317aa
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Molecular Weight
19.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UTY, a testis-specific protein encoded by the UTY gene located on the Y chromosome, has gained significant attention in research due to its role in male-specific biological processes. As a member of the TRDMT1 family, UTY is implicated in various cellular functions, including chromatin remodeling and gene regulation, thereby influencing spermatogenesis and potentially contributing to male fertility. Recent studies have suggested that UTY may play critical roles in epigenetic regulation, particularly in the context of male germ cell development and function. Given that UTY expression is primarily restricted to the testis, it presents a unique opportunity to explore its function in a sex-specific context, particularly in the face of differences observed in sexual dimorphism at the genetic level. Additionally, UTY's potential involvement in the pathogenesis of male infertility and its implications for reproductive health make it a promising target for further investigation. Understanding the molecular mechanisms regulated by UTY could not only shed light on fundamental aspects of male reproductive biology but also facilitate the development of therapeutic strategies for related disorders. Research into UTY’s structure, function, and interaction with other proteins is critical in uncovering its precise contributions to male gametogenesis and overall reproductive success, highlighting its relevance in both basic science and potential clinical applications.
