Analytical Data
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基因名
AKR7A2
- Application
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别名
AKR7A2；AFAR；AFAR1；AKR7；Aflatoxin B1 aldehyde reductase member 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43488
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表达区间
1-359aa
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氨基酸序列
MLSAASRVVS RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR MDAPASAAAV RAFLERGHTE LDTAFMYSDG QSETILGGLG LGLGGGDCRV KIATKANPWD GKSLKPDSVR SQLETSLKRL QCPQVDLFYL HAPDHGTPVE ETLHACQRLH QEGKFVELGL SNYASWEVAE ICTLCKSNGW ILPTVYQGMY NATTRQVETE LFPCLRHFGL RFYAYNPLAG GLLTGKYKYE DKDGKQPVGR FFGNSWAETY RNRFWKEHHF EAIALVEKAL QAAYGASAPS VTSAALRWMY HHSQLQGAHG DAVILGMSSL EQLEQNLAAT EEGPLEPAVV DAFNQAWHLV AHECPNYFR
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKR7A2, a member of the aldo-keto reductase (AKR) superfamily, plays a critical role in the metabolism of various endogenous and exogenous substrates, including steroid hormones, pharmacological agents, and xenobiotics. Research indicates that AKR7A2 is involved in detoxification processes and the regulation of cellular stress responses, highlighting its potential implications in various diseases, including cancer and metabolic disorders. Its ability to reduce aldehydes and ketones to their respective alcohols suggests a protective function against oxidative stress and other harmful cellular conditions. Moreover, AKR7A2 has garnered attention due to its varying expression levels in different tissues and its association with specific pathological states. Understanding the structure-function relationship of AKR7A2 through recombinant protein studies can provide insights into its enzymatic mechanisms and regulatory pathways. This knowledge may pave the way for novel therapeutic approaches targeting AKR7A2 for disease intervention, making it a significant focus of ongoing biochemical and pharmacological research.
