Cat: PA1000-112DB

Recombinant Human AKR7A2 Protein,His

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Analytical Data

  • Gene name

    AKR7A2

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    AKR7A2;AFAR;AFAR1;AKR7;Aflatoxin B1 aldehyde reductase member 2

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    O43488

  • Expression Region

    1-359aa

  • AA Sequence

    MLSAASRVVS RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR MDAPASAAAV RAFLERGHTE LDTAFMYSDG QSETILGGLG LGLGGGDCRV KIATKANPWD GKSLKPDSVR SQLETSLKRL QCPQVDLFYL HAPDHGTPVE ETLHACQRLH QEGKFVELGL SNYASWEVAE ICTLCKSNGW ILPTVYQGMY NATTRQVETE LFPCLRHFGL RFYAYNPLAG GLLTGKYKYE DKDGKQPVGR FFGNSWAETY RNRFWKEHHF EAIALVEKAL QAAYGASAPS VTSAALRWMY HHSQLQGAHG DAVILGMSSL EQLEQNLAAT EEGPLEPAVV DAFNQAWHLV AHECPNYFR

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

AKR7A2, a member of the aldo-keto reductase (AKR) superfamily, plays a critical role in the metabolism of various endogenous and exogenous substrates, including steroid hormones, pharmacological agents, and xenobiotics. Research indicates that AKR7A2 is involved in detoxification processes and the regulation of cellular stress responses, highlighting its potential implications in various diseases, including cancer and metabolic disorders. Its ability to reduce aldehydes and ketones to their respective alcohols suggests a protective function against oxidative stress and other harmful cellular conditions. Moreover, AKR7A2 has garnered attention due to its varying expression levels in different tissues and its association with specific pathological states. Understanding the structure-function relationship of AKR7A2 through recombinant protein studies can provide insights into its enzymatic mechanisms and regulatory pathways. This knowledge may pave the way for novel therapeutic approaches targeting AKR7A2 for disease intervention, making it a significant focus of ongoing biochemical and pharmacological research.

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