Analytical Data
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Gene name
KCNK9
- Application
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Alternative Names
(Acid-sensitive potassium channel protein TASK-3)(TWIK-related acid-sensitive K(+) channel 3)(Two pore potassium channel KT3.2)(Two pore K(+) channel KT3.2)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NPC2
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Expression Region
1-374aa
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Molecular Weight
48.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNK9, also known as TREK-2, is a member of the two-pore domain potassium channel family and plays a crucial role in maintaining cellular excitability and regulating neuronal and cardiac functions. Its dysregulation has been implicated in various pathophysiological conditions, including neurological disorders, cardiac arrhythmias, and tumorigenesis. Research on KCNK9 recombinant proteins has garnered attention due to their potential therapeutic applications, particularly in developing new treatments for diseases associated with ion channel dysfunction. The characterization of KCNK9 recombinant proteins allows for a deeper understanding of their functional properties, such as ion selectivity, gating mechanisms, and regulatory pathways. Additionally, insights gained from KCNK9 studies can inform drug discovery efforts, especially in identifying small molecules that can modulate its activity. Given the importance of ion channels in cellular homeostasis and signaling, exploring KCNK9’s structure-function relationships and its interactions with pharmacological agents represents a significant frontier in biomedical research. This ongoing research aims to unveil the physiological significance of KCNK9, which could lead to innovative strategies for managing diseases linked to its misregulation.
