Analytical Data
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基因名
KCNK13
- Application
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别名
(Tandem pore domain halothane-inhibited potassium channel 1)(THIK-1)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HB14
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表达区间
1-408aa
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分子量
51.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNK13, a member of the potassium channel family, encodes a potassium ion channel that plays a crucial role in regulating the membrane potential and excitability of various cell types. Research into KCNK13 has gained significant attention due to its potential implications in both physiological and pathological processes, including neuronal signaling, cardiac function, and the regulation of smooth muscle contraction. Studies have shown that KCNK13 is expressed in several tissues, including the brain, lungs, and muscles, suggesting it has diverse functional roles. Moreover, abnormal function of KCNK13 has been linked to several disease states, such as epilepsy and other neurological disorders, prompting interest in its structure and function. The generation of recombinant KCNK13 protein has enabled researchers to explore its biophysical properties, ion selectivity, and pharmacological modulation, providing insights into its mechanism of action. Understanding KCNK13's function at a molecular level is essential for developing potential therapeutic strategies targeting its dysregulation in various diseases. Thus, the study of KCNK13 recombinant protein serves as a pivotal step in elucidating the broader roles of potassium channels in cellular physiology and their importance in maintaining homeostasis within the body.












