Analytical Data
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基因名
AES
- Application
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别名
AES；AES；GRG；GRG5；TLE family member 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08117
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表达区间
1-197aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMMFPQSRHSGSSHLPQQLKFTTSDSCDRIK DEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAE IVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAH QLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDK NGHDGDTHQEDDGEKSD
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分子量
24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of AES (Amphiphysin 1) recombination proteins has garnered significant attention in the fields of molecular biology and medicine due to their essential roles in various cellular processes, including endocytosis, synaptic transmission, and nervous system development. AES is a member of the BAR (Bin/Amphiphysin/Rvs) domain-containing family of proteins, which are known for their ability to sense and generate membrane curvature, thus influencing membrane dynamics and vesicle formation. Abnormal expression or malfunctioning of AES proteins has been implicated in several neurological disorders, such as Alzheimer's disease and autism spectrum disorders. Research has increasingly focused on understanding the molecular mechanisms by which AES interacts with other proteins and membranes, as well as exploring potential therapeutic targets for modulating its activity. Furthermore, advances in methods for protein engineering and recombinant DNA technology have opened new avenues for the creation of modified AES proteins, allowing researchers to dissect their functional roles in a controlled manner. This has laid the groundwork for innovative strategies in drug discovery and the development of novel biotechnological applications, emphasizing the importance of AES recombination proteins in both basic research and clinical contexts.
