Analytical Data
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Gene name
STAM2
- Application
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Alternative Names
STAM2；HBP；Signal transducing adapter molecule 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75886
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Expression Region
1-525aa
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AA Sequence
MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAI MKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNK AHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQT VSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLN NKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGL FPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRA LQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSEL NVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSH GGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLS TGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQL AGFPVTVPAHPVAQQHTNYHQQPLL
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Molecular Weight
83 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STAM2 (signal transducing adaptor molecule 2) is a critical component involved in multiple cellular processes, including signal transduction, endocytosis, and autophagy. It is a member of the STAM family, which plays a pivotal role in the modulation of signaling pathways, particularly in the context of receptor activation and downstream effects. The protein functions primarily as an adaptor that links ubiquitinated proteins to the endosomal sorting complex required for transport (ESCRT) machinery, facilitating the sorting and degradation of membrane proteins. Recent studies have demonstrated that STAM2 is implicated in various pathophysiological conditions, including cancer, neurodegenerative diseases, and metabolic disorders. The interest in STAM2 recombinant proteins is driven by their potential utility in elucidating the underlying mechanisms of these diseases, as well as their role in cellular signaling networks. By producing and characterizing STAM2 recombinant proteins, researchers aim to gain insights into its structural and functional properties, investigate its interactions with other molecules, and explore its therapeutic potential. The advancement of recombinant protein technology allows for the generation of large quantities of STAM2, which can be used in biochemical assays, structural biology studies, and drug discovery efforts. As such, the study of STAM2 recombinant proteins holds significant promise for enhancing our understanding of cellular physiology and developing novel therapeutic strategies targeting STAM2-related pathways.
