Analytical Data
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Gene name
ADPRH
- Application
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Alternative Names
ADPRH；ARH1；ADP-ribosylhydrolase ARH1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54922
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Expression Region
1-357aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMEKYVA AMVLSAAGDA LGYYNGKWEF LQDGEKIHRQ LAQLGGLDAL DVGRWRVSDD TVMHLATAEA LVEAGKAPKL TQLYYLLAKH YQDCMEDMDG RAPGGASVHN AMQLKPGKPN GWRIPFNSHE GGCGAAMRAM CIGLRFPHHS QLDTLIQVSI ESGRMTHHHP TGYLGALASA LFTAYAVNSR PPLQWGKGLM ELLPEAKKYI VQSGYFVEEN LQHWSYFQTK WENYLKLRGI LDGESAPTFP ESFGVKERDQ FYTSLSYSGW GGSSGHDAPM IAYDAVLAAG DSWKELAHRA FFHGGDSDST AAIAGCWWGV MYGFKGVSPS NYEKLEYRNR LEETARALYS LGSKEDTVIS L
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Molecular Weight
42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADPRH (ADP-ribose glycohydrolase) is an important enzyme involved in the metabolism of ADP-ribose, a critical molecule in cellular processes such as DNA repair, signal transduction, and apoptosis. Its role in modulating the cellular response to stress and maintaining genomic integrity has garnered significant interest in the fields of molecular biology and cancer research. The enzyme functions by hydrolyzing ADP-ribose, regulating its levels within cells, and ensuring proper cellular function. Dysregulation or mutations in ADPRH have been associated with various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Consequently, understanding the structure and function of ADPRH, particularly through the study of its recombinant forms, has become essential for elucidating its biological roles and therapeutic potential. Studies on recombinant ADPRH aim to characterize its enzymatic activity, identify critical residues involved in its function, and explore its interactions with other cellular proteins. Furthermore, the development of ADPRH inhibitors could pave the way for novel therapeutic strategies against diseases linked to its dysfunction, highlighting the significance of this research in advancing our understanding of cellular signaling pathways and disease mechanisms.
