Cat: PA1000-8923

Recombinant Human STAM1 Protein,His

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Analytical Data

  • Gene name

    STAM1

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    STAM1;STAM1;Signal transducing adapter molecule 1

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    P70297

  • Expression Region

    2-548aa

  • AA Sequence

    PLFATNPFDQDVEKATSELNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHV AMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKN DPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIE LSLKEQRQQSAPVSTLYPSTSNLLTNHQHEGRKVRAVYDFEAAEDNELTFKAGEIITVLD DSDPNWWKGETHQGVGLFPSNFVTADLTAEPEMIKTEKKTVQFNDDVQIETIEPEPEPAF IDEDKMDQLLQMLQSTDPSDNQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELN VKVMEALSLYTKLMNEDPMYSMYAKLQSQQYYLQSSAVSASQVYPGPAQSGTYLVAGSAQ MTHLQSYSLPPEQLSSISQGAVPSSANQALPSQQTQASYPNAMVSSVQGNSYPSQASIYS PPAAAAAAAAAAVVPVPVPADVTIYQNAGPTMSQVPNYTLTSSTLPQTGGSQQPPQPQQA YSQKALL

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

STAM1 (Signal Transducer and Activator of Transcription 1) is a critical adaptor protein that plays a significant role in various cellular processes, including signal transduction, immune response, and apoptosis. Its unique structure, which includes a VHS (Vps27p/Hrs/STAM) domain and a PTB (phosphotyrosine-binding) domain, enables it to interact with multiple signaling pathways, notably those activated by cytokines and growth factors. Research into STAM1 has gained momentum as its dysregulation has been associated with various diseases, including cancers and immune disorders. Understanding the molecular mechanisms underlying STAM1 function is essential for developing targeted therapeutic strategies. Recombinant STAM1 protein has become a vital tool in these studies, allowing researchers to dissect its interactions and functions in detail. By employing techniques such as X-ray crystallography and mass spectrometry, scientists aim to elucidate the structural and functional aspects of STAM1, providing insights into its role in physiological and pathological processes. This knowledge could pave the way for innovative treatments that modulate STAM1's activity, thus influencing disease outcomes and enhancing therapeutic efficacy.

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