Analytical Data
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Gene name
VPS13D
- Application
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Alternative Names
VPS13D；KIAA0453；Intermembrane lipid transfer Protein VPS13D
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5THJ4
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Expression Region
3276-3558aa
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AA Sequence
lKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLDYAWDEPTL
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Molecular Weight
38.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VPS13D is a member of the VPS13 family of proteins, which are integral in various cellular processes, including lipid transport and mitochondrial function. Mutations in the VPS13D gene have been linked to neurodegenerative disorders, such as chorea-acanthocytosis and other movement disorders, underscoring its significance in neuronal health. Recent studies have highlighted the role of VPS13D in autophagy, endosomal trafficking, and membrane contact sites, which are crucial for maintaining cellular homeostasis. Understanding the function of VPS13D is essential for elucidating the molecular mechanisms underlying these diseases and could potentially lead to novel therapeutic strategies. Researchers have focused on characterizing the protein's structure, interactions, and biochemical pathways to gain insights into its role in lipid metabolism and neuronal integrity. The recombinant expression of VPS13D serves as a valuable tool in these investigations, providing a means to study its functional properties and interactions in vitro, which may enhance our understanding of how its dysregulation contributes to pathologies. Overall, the ongoing research on VPS13D is pivotal in bridging the gap between basic biochemical functions and their implications in human health, paving the way for future clinical applications.
