Analytical Data
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Gene name
OSGIN1
- Application
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Alternative Names
OSGIN1；BDGI；OKL38；Oxidative stress-induced growth inhibitor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UJX0
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Expression Region
1-560aa
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AA Sequence
MGKWRPRGCC RGNMQCRQEV PATLTSSELF STRNQPQPQP QPLLADAPVP WAVASRMCLT PGQGCGHQGQ DEGPLPAPSP PPAMSSSRKD HLGASSSEPL PVIIVGNGPS GICLSYLLSG YTPYTKPDAI HPHPLLQRKL TEAPGVSILD QDLDYLSEGL EGRSQSPVAL LFDALLRPDT DFGGNMKSVL TWKHRKEHAI PHVVLGRNLP GGAWHSIEGS MVILSQGQWM GLPDLEVKDW MQKKRRGLRN SRATAGDIAH YYRDYVVKKG LGHNFVSGAV VTAVEWGTPD PSSCGAQDSS PLFQVSGFLT RNQAQQPFSL WARNVVLATG TFDSPARLGI PGEALPFIHH ELSALEAATR VGAVTPASDP VLIIGAGLSA ADAVLYARHY NIPVIHAFRR AVDDPGLVFN QLPKMLYPEY HKVHQMMREQ SILSPSPYEG YRSLPRHQLL CFKEDCQAVF QDLEGVEKVF GVSLVLVLIG SHPDLSFLPG AGADFAVDPD QPLSAKRNPI DVDPFTYQST RQEGLYAMGP LAGDNFVRFV QGGALAVASS LLRKETRKPP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSGIN1 (Oxidative Stress Inducible Gene 1) is a protein implicated in cellular responses to oxidative stress, a condition characterized by excessive reactive oxygen species (ROS) that can lead to cellular damage and contribute to various diseases, including cancer and neurodegenerative disorders. The role of OSGIN1 in modulating oxidative stress responses has garnered significant interest among researchers, as understanding its function may provide insights into the mechanisms of cellular survival and death under stress conditions. Studies have shown that OSGIN1 is upregulated in response to oxidative stress, suggesting its protective role in enhancing cellular resilience. Furthermore, OSGIN1 interacts with several signaling pathways involved in apoptosis and cell survival, highlighting its potential as a therapeutic target. Research aims to characterize the protein's structure, function, and interactions at the molecular level, which may lead to the development of novel strategies for disease intervention. Cloning and expression of recombinant OSGIN1 are essential steps in these studies, enabling researchers to produce sufficient quantities of the protein for functional assays and structural analyses. Ultimately, elucidating the precise role of OSGIN1 in oxidative stress responses could provide valuable information for therapeutic development and a deeper understanding of the cellular mechanisms governing oxidative damage and repair.
