Analytical Data
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基因名
CORIN
- Application
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别名
(Corin)(Heart-specific serine proteinase ATC2)(Pro-ANP-converting enzyme)(Transmembrane protease serine 10)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5Q5
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表达区间
1-110aa
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分子量
16.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CORIN is a membrane-bound serine protease that plays a crucial role in the regulation of blood pressure and fluid homeostasis. It specifically activates pro-atrial natriuretic peptide (pro-ANP) to ANP, which is vital for cardiovascular health. Dysregulation of CORIN has been associated with various cardiovascular diseases, including heart failure and hypertension. Research on CORIN and its recombinant protein has gained significant attention, as understanding its structure and function can provide insights into its therapeutic potential. Recombinant CORIN proteins are being explored for their utility in both basic research and clinical applications, such as the development of novel treatments for heart-related conditions. Additionally, studying CORIN can enhance our understanding of the natriuretic peptide system and its implications in cardiovascular physiology and pathology. As the prevalence of cardiovascular diseases continues to rise globally, advancements in CORIN research hold promise for innovative therapeutic strategies aimed at improving patient outcomes.
