Analytical Data
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Gene name
COG5
- Application
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Alternative Names
(COG complex subunit 5)(13S Golgi transport complex 90 kDa subunit)(GTC-90)(Component of oligomeric Golgi complex 5)(Golgi transport complex 1)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UP83
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Expression Region
1-257aa
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Molecular Weight
33.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
COG5, a key component of the conserved oligomeric Golgi (COG) complex, plays a critical role in the maintenance of Golgi apparatus structure and function, particularly in regulating the trafficking of glycoproteins and maintaining cellular homeostasis. Research has shown that mutations in COG5 can lead to developmental disorders, notably Congenital Disorders of Glycosylation (CDG), which are characterized by defective glycoprotein synthesis. The COG complex, comprising multiple subunits, is essential for retrograde transport from the Golgi back to the endoplasmic reticulum, thereby ensuring proper protein modification and processing. Investigating COG5 through recombinant protein studies is crucial for elucidating its specific functions and interactions within the COG complex, as well as its broader implications in cellular biology. Recent advances in recombinant protein expression systems allow for the detailed characterization of COG5, contributing to a deeper understanding of its role in glycosylation pathways and disease mechanisms. This research not only enhances our knowledge of basic cell biology but also has potential therapeutic implications for CDG and related disorders, highlighting the significance of COG5 in both health and disease.
