Analytical Data
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Gene name
esxH
- Application
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Alternative Names
10KDA antigen CFP7 ;CFP-7Low molecular weight protein antigen 7Protein TB10.4
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Species
Mycobacterium tuberculosis
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P9WNK2
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Expression Region
2-96aa
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Molecular Weight
26.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of the esxH recombinant protein is rooted in the understanding of its role in the pathogenesis of various infectious diseases, particularly those caused by Mycobacterium tuberculosis (Mtb). EsxH is a member of the ESX (type VII secretion) system, which is crucial for the virulence and immune evasion of pathogenic mycobacteria. Research has shown that proteins secreted via this system, including esxH, play a significant role in modulating host immune responses, thereby aiding in bacterial survival and persistence within the host. Given the global burden of tuberculosis and the rise of drug-resistant strains, investigating the biochemical properties and functional implications of esxH is vital for the development of novel therapeutic strategies and vaccines. Furthermore, characterization of esxH can enhance our understanding of the molecular mechanisms underlying Mtb’s interaction with the immune system, paving the way for potential interventions that could improve disease outcomes. As such, research into esxH not only contributes to a deeper comprehension of mycobacterial biology but also has important implications for public health and disease control efforts.
