Analytical Data
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Gene name
mpt51
- Application
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Alternative Names
mpt51; fbpC1; fbpD; mpb51; MT3910; MPT51/MPB51 antigen
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Species
Mycobacterium tuberculosis
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P9WQN6
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Expression Region
27-299aa
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Molecular Weight
44.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MPT51 protein, derived from Mycobacterium tuberculosis, has gained significant interest in immunological and vaccine research due to its potential role in tuberculosis (TB) pathogenesis. This protein is part of the mammalian protein translation (MPT) family, which is believed to have significant effects on the host immune response. Studies have shown that MPT51 can modulate immune cell functions, such as activating macrophages and influencing T-cell responses, which are critical in combating TB. Given that TB remains one of the leading causes of infectious disease-related mortality worldwide, understanding the function and structure of MPT51 is crucial for developing novel diagnostic tools and effective vaccines. Research efforts have focused on elucidating the biochemical properties of MPT51, its interaction with host immune components, and its potential to serve as a biomarker for TB infection. The recombinant production of MPT51 has enabled researchers to explore its immunogenicity and therapeutic applications further, including its possible use in immunization strategies. By investigating the molecular mechanisms through which MPT51 affects host immunity, researchers aim to identify new avenues for TB treatment and prevention, ultimately contributing to global health initiatives aimed at eradicating this devastating disease.
