Analytical Data
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基因名
MAPT
- Application
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别名
MAPT；MAPTL；MTBT1；TAU；Microtubule-associated Protein tau
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种属
Human
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表达系统
E. coli
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标签
C-his
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10636
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表达区间
1-441aa
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氨基酸序列
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
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分子量
51.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAPT, or Microtubule-Associated Protein Tau, is a crucial protein in the study of neurodegenerative diseases, particularly Alzheimer's disease and other tauopathies. It plays a significant role in stabilizing microtubules within neuronal cells, ensuring proper cell structure and function. However, under pathological conditions, tau becomes hyperphosphorylated and aggregates to form neurofibrillary tangles, a hallmark of Alzheimer's disease. This abnormal aggregation disrupts microtubule stability and impairs neuronal transport, contributing to neurodegeneration. Research into MAPT and its protein isoforms, particularly the changes in its expression and post-translational modifications, aims to elucidate the mechanisms underlying tauopathies and identify potential therapeutic targets. Additionally, genetic variations in the MAPT gene have been linked to increased susceptibility to neurodegenerative diseases, leading to further investigations into its role in disease risk. Understanding MAPT's structure, function, and the molecular pathways involving its dysregulation is essential for developing strategies to combat tau-related diseases and improve patient outcomes.
