Analytical Data
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Gene name
MAPT
- Application
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Alternative Names
MAPT；MAPTL；MTBT1；TAU；Microtubule-associated Protein tau
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Species
Human
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Source
E. coli
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Tag
C-his
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10636
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Expression Region
1-441aa
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AA Sequence
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
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Molecular Weight
51.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAPT, or Microtubule-Associated Protein Tau, is a crucial protein in the study of neurodegenerative diseases, particularly Alzheimer's disease and other tauopathies. It plays a significant role in stabilizing microtubules within neuronal cells, ensuring proper cell structure and function. However, under pathological conditions, tau becomes hyperphosphorylated and aggregates to form neurofibrillary tangles, a hallmark of Alzheimer's disease. This abnormal aggregation disrupts microtubule stability and impairs neuronal transport, contributing to neurodegeneration. Research into MAPT and its protein isoforms, particularly the changes in its expression and post-translational modifications, aims to elucidate the mechanisms underlying tauopathies and identify potential therapeutic targets. Additionally, genetic variations in the MAPT gene have been linked to increased susceptibility to neurodegenerative diseases, leading to further investigations into its role in disease risk. Understanding MAPT's structure, function, and the molecular pathways involving its dysregulation is essential for developing strategies to combat tau-related diseases and improve patient outcomes.
