Analytical Data
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基因名
Atp1a3
- Application
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别名
Sodium/potassium-transporting ATPase subunit alpha-3(Na(+)/K(+) ATPase alpha-3 subunit)(EC 7.2.2.13)(Na(+)/K(+) ATPase alpha(III) subunit)(Sodium pump subunit alpha-3)
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种属
Rat
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06687
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表达区间
329-762aa
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分子量
54.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP1A3 is an essential gene that encodes the alpha-3 subunit of the sodium-potassium ATPase, an enzyme critical for maintaining ionic gradients across cellular membranes. This protein is predominantly expressed in the central nervous system and plays a significant role in neuronal excitability and signal transmission. Mutations in ATP1A3 have been linked to several neurological disorders, including Alternating Hemiplegia of Childhood (AHC) and other related syndromes. Research on recombinant ATP1A3 protein is crucial for understanding the physiological roles of this enzyme, elucidating the mechanisms by which mutations cause disease, and developing targeted therapies. Recombinant protein production allows for detailed biochemical characterizations, such as activity assays and structural analyses, which provide insights into the functional consequences of specific mutations. Additionally, studying ATP1A3 in a controlled laboratory environment enables the exploration of its interaction with other proteins and cellular components, further revealing its role in neuronal health and disease. Overall, research aimed at understanding ATP1A3 through recombinant protein methodologies is vital for advancing our knowledge of its function and potential therapeutic strategies for related neurological conditions.
