Analytical Data
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Gene name
UL83
- Application
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Alternative Names
65KDA matrix phosphoprotein Phosphoprotein UL83 Tegument protein UL83
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Species
Human cytomegalovirus
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P06725
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Expression Region
351-480aa
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Molecular Weight
18.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UL83, also known as the immediate-early protein 1 (IE1) of human cytomegalovirus (HCMV), plays a crucial role in the virus's life cycle and pathogenesis. Research into UL83 is primarily motivated by its significant functions in viral replication and host immune evasion. As an immediate-early protein, UL83 is expressed soon after HCMV infects a host cell, regulating the transcription of early and late viral genes, which is essential for efficient viral proliferation. Additionally, UL83 has been shown to interfere with host cell signaling pathways and immune responses, enabling the virus to evade detection and clearance by the immune system. The study of UL83 is of particular interest in the context of viral latency and reactivation, which are critical challenges in chronic infections and in transplant patients where HCMV can lead to serious complications. Understanding the structure and function of UL83 can provide insights into therapeutic strategies for targeting HCMV, potentially leading to the development of vaccines or antiviral agents. As such, UL83 is not only a vital component of HCMV biology but also a promising target for future research aimed at controlling HCMV-associated diseases.
