Analytical Data
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基因名
Thanatin
- Application
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种属
Podisus maculiventris
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表达系统
E. coli
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标签
N- His-KSI
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P55788
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表达区间
1-21aa
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分子量
17.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Thanatin is a potent antimicrobial peptide derived from the Tobacco Hornworm, Manduca sexta, known for its ability to combat a wide range of pathogens, including bacteria, fungi, and viruses. It belongs to the group of insect defensins, which are crucial components of the innate immune system in insects. The unique structure of Thanatin, characterized by a conserved α-helical region, contributes to its effectiveness in disrupting microbial membranes. Recent research has focused on the recombinant expression of Thanatin in various host systems, such as bacteria and yeast, to facilitate its production and study. This approach allows for a more accessible and scalable method of obtaining the peptide for further investigations into its mechanisms of action and potential therapeutic applications. Given the rising problem of antibiotic resistance, Thanatin and its derivatives are being explored as alternatives or complementary treatments to conventional antibiotics. Studies have shown promising results regarding its efficacy against multidrug-resistant strains, making Thanatin a subject of interest in the development of novel antimicrobial agents. The ongoing research aims to optimize its production, understand its interaction with microbial targets, and evaluate its safety and effectiveness in clinical settings, positioning Thanatin as a potential key player in the fight against infectious diseases.
