Analytical Data
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Gene name
cdtC
- Application
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Alternative Names
CDT C
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Species
Escherichia coli
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q46670
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Expression Region
16-181aa
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Molecular Weight
25.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of recombinant cdtC protein has emerged as a significant focus in microbial pathogenicity research, particularly concerning the bacterium *Helicobacter pylori*. This bacterium is notorious for its role in chronic gastritis, peptic ulcers, and even gastric cancer. The cdtC gene encodes a component of the cytolethal distending toxin (CDT), a virulence factor that affects host cells by inducing cell cycle arrest and apoptosis. Understanding the structure and function of the cdtC protein is crucial, as it may reveal potential therapeutic targets and contribute to the development of vaccines. Recent advances in genetic engineering have facilitated the production of recombinant cdtC proteins, enabling detailed studies of their immunogenic properties and interactions with host immune responses. Additionally, investigations into the functional mechanisms of CDT have underscored its role in immune evasion, making it even more relevant for therapeutic strategies against *H. pylori*-associated diseases. Furthermore, the recombinant form of cdtC can be exploited in experimental models to assess its effects on host cells, paving the way for a deeper understanding of pathogenic mechanisms and the design of novel intervention strategies. As research continues to unravel the complexities of the cdtC protein and its implications in *H. pylori* pathogenesis, it holds promise for enhancing our comprehension of bacterial virulence factors and their impact on human health.
