Analytical Data
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Gene name
INGAP
- Application
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Alternative Names
Islet neogenesis-associated protein
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Species
Golden hamster
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92778
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Expression Region
27-175aa
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Molecular Weight
22.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
INGAP (Islet Neogenesis Associated Protein) is a key protein implicated in the regeneration of pancreatic beta cells, which are crucial for insulin production and glucose metabolism. Research into INGAP has gained significant momentum due to the rising prevalence of diabetes, a condition that results from the dysfunction or loss of beta cells. In the early 1990s, INGAP was identified as a protein associated with islet neogenesis, the process by which new islet cells form in the pancreas. Subsequent studies have demonstrated that INGAP not only plays a role in promoting beta-cell proliferation under certain conditions but may also enhance the survival of these cells. Additionally, the ability of INGAP to stimulate the differentiation of progenitor cells into functional beta cells has raised interest in its potential therapeutic applications for diabetes. Understanding the molecular mechanisms underlying INGAP's action could lead to innovative treatment strategies, including the development of new drugs or regenerative therapies aimed at restoring beta-cell function. Ongoing research is focusing on characterizing the structural properties of INGAP, elucidating its signaling pathways, and testing its efficacy in preclinical models of diabetes. The insights gained from these studies hold promise for advancing our knowledge of pancreatic regeneration and ultimately improving clinical outcomes for patients suffering from diabetes.
