Analytical Data
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Gene name
IFM1
- Application
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Alternative Names
IFM1; YOL023WTranslation initiation factor IF-2; mitochondrial; IF-2(Mt); IF-2Mt; IF2(mt)
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Species
Saccharomyces cerevisiae
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25038
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Expression Region
43-676aa
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Molecular Weight
97.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFM1, or Interferon-inducible protein 16 (IFI16), is a critical component of the innate immune response, primarily known for its role in recognizing viral DNA and stimulating antiviral defenses. Recent studies have shown that IFM1 acts not only as a DNA sensor but also plays a significant role in regulating immune responses and inflammation. Its ability to form complexes with various proteins highlights its involvement in signaling pathways that modulate cellular responses to viral infections. Given its importance in the immune system, researchers have focused on the development of recombinant IFM1 proteins to better understand their structure-function relationships and therapeutic potential. By employing recombinant DNA technology, scientists can produce large quantities of IFM1, allowing for in-depth studies of its mechanisms of action and interactions with other cellular components. Additionally, exploring the role of IFM1 in different diseases, including autoimmune disorders and cancers, may provide insights into novel therapeutic approaches. Enhanced understanding of IFM1 through recombinant protein studies could pave the way for innovative strategies in targeting viral infections and modulating immune responses. The ongoing research into IFM1 not only expands our knowledge of the innate immune system but also holds promise for the development of new immunotherapeutic agents that harness its antiviral and regulatory properties.
