Analytical Data
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Gene name
MAST4
- Application
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Alternative Names
MAST4; MAST4_HUMAN; Microtubule associated serine/threonine protein kinase member 4; Microtubule-associated serine/threonine-protein kinase 4
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15021
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Expression Region
1140-1231aa
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Molecular Weight
17.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAST4 (Microtubule-associated serine/threonine kinase 4) is a member of the MAST (Microtubule-associated serine/threonine) kinase family, which plays a crucial role in regulating microtubule dynamics and cellular processes such as mitosis, migration, and intracellular transport. The study of MAST4 is particularly significant due to its potential implications in cancer biology and neurodegenerative diseases, where aberrant microtubule dynamics can contribute to tumor progression and neuronal dysfunction. Recent research has indicated that MAST4 is overexpressed in various cancer types, suggesting a role in tumorigenesis and poor patient prognosis. Additionally, its kinase activity influences cell cycle progression and apoptosis, making it a potential target for therapeutic intervention. Understanding the structural and functional characteristics of MAST4, especially through recombinant protein studies, can provide insights into its mechanisms of action, interactions with microtubules, and regulatory pathways. Such investigations are critical not only for elucidating the biological roles of MAST4 but also for developing targeted strategies for cancer treatment and understanding its function in neuronal health. This background highlights the importance of MAST4 as a significant player in cellular dynamics and disease, paving the way for future studies aimed at harnessing its potential in clinical applications.
