Analytical Data
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Gene name
UBC11
- Application
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Alternative Names
E2 ubiquitin-conjugating enzyme 11 Ubiquitin carrier protein 11 Ubiquitin-conjugating enzyme E2-17 kDa 11 Ubiquitin-protein ligase 11
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Species
Arabidopsis thaliana
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35134
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Expression Region
1-148aa
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Molecular Weight
20.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBC11, a member of the ubiquitin-conjugating enzyme family, plays a crucial role in the ubiquitin-proteasome pathway, which regulates protein degradation and various cellular processes. The protein is involved in tagging substrates with ubiquitin, thereby dictating their fate in the cellular environment. Previous studies have highlighted UBC11's significant involvement in stress responses, cell cycle regulation, and developmental processes in various organisms. The exploration of UBC11 is particularly relevant given the increasing recognition of ubiquitin-mediated signaling in physiological and pathological contexts, including cancer and neurodegenerative diseases. Understanding the structure and function of UBC11 can provide insights into its specificity for different substrates and elucidate its role in disease mechanisms. Research into the recombinant production of UBC11 has gained momentum, aiming to facilitate detailed biochemical characterization, such as threedimensional structure analysis and the identification of interaction partners. Enhanced knowledge of UBC11 may pave the way for novel therapeutic strategies targeting ubiquitination pathways, underscoring its potential as a biomarker or a target for drug development in the context of diseases linked to protein misfolding or degradation dysregulation. Overall, UBC11 remains a focal point of biochemical research due to its pivotal role in maintaining cellular homeostasis and its implications in various disease states.
