Analytical Data
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Gene name
UGT1A4
- Application
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Alternative Names
UDPGT 1-4 Short name: UGT1*4 Short name: UGT1-04 Short name: UGT1.4 Alternative name(s): Bilirubin-specific UDPGT isozyme 2 Short name: hUG-BR2 UDP-glucuronosyltransferase 1-D Short name: UGT-1D Short name: UGT1D UDP-glucuronosyltransferase 1A4
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P22310
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Expression Region
29-534aa
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Molecular Weight
61 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UGT1A4 (UDP-glucuronosyltransferase 1A4) is a key enzyme involved in the metabolism of various endogenous and exogenous compounds, including drugs and environmental toxins, through glucuronidation. This process is crucial for detoxification, enhancing water solubility, and facilitating the excretion of these substances from the body. Variations in UGT1A4 expression or activity can significantly impact drug efficacy and toxicity, making it a focal point of pharmacogenomic studies. Research into UGT1A4 recombinant proteins aims to elucidate the enzyme's functional characteristics, including substrate specificity and kinetic parameters, which are vital for understanding individual responses to therapeutics. Additionally, expressing UGT1A4 in heterologous systems enables the study of its interactions with various drugs and aids in the identification of potential drug-drug interactions. Investigating UGT1A4's role in disease states, such as cancer and metabolic disorders, further underscores its importance in personalized medicine, where tailoring treatment based on genetic makeup can optimize therapeutic outcomes. Overall, the study of UGT1A4 recombinant proteins provides essential insights into drug metabolism, safety assessments, and the development of novel therapeutic strategies.
