Analytical Data
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Gene name
RBFOX2
- Application
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Alternative Names
Fox-1 homolog BHexaribonucleotide-binding protein 2RNA-binding motif protein 9RNA-binding protein 9Repressor of tamoxifen transcriptional activity
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43251
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Expression Region
1-380aa
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Molecular Weight
44.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBFOX2, a member of the RBFOX family of splicing regulators, plays a crucial role in the regulation of alternative splicing, which is a vital process that contributes to the diversity of the transcriptome and ultimately the proteome in eukaryotic cells. This protein is known to be involved in neuronal development and muscle differentiation, and its dysregulation has been implicated in various diseases, including neurodegenerative disorders and cancers. Research into RBFOX2 has gained momentum due to its potential as a therapeutic target and biomarker. The study of recombinant RBFOX2 protein allows for a deeper understanding of its structure-function relationship, interaction with RNA, and involvement in splicing regulation. By producing RBFOX2 in a recombinant system, researchers can investigate the protein’s biochemical properties, study its role in splicing mechanisms, and explore its interactions with other cellular molecules. Understanding these facets is essential for elucidating the broader implications of RBFOX2 in health and disease, particularly in conditions characterized by aberrant splicing events. Furthermore, recombinant RBFOX2 provides a valuable tool for drug screening and the development of novel therapeutic strategies aimed at correcting splicing defects associated with various diseases. Overall, research on RBFOX2 and its recombinant protein form is pivotal in advancing our knowledge of RNA biology and its implications in pathology.
