Analytical Data
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基因名
RAN
- Application
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别名
Androgen receptor-associated protein 24 GTPase Ran Ras-like protein TC4 Ras-related nuclear protein
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P62826
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表达区间
1-216aa
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分子量
51.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAN (Ras-related nuclear protein) is a small GTPase that plays a crucial role in nucleocytoplasmic transport, cell cycle progression, and mitosis by regulating the transport of proteins and RNA across the nuclear envelope. The RAN protein functions by switching between an active GTP-bound state and an inactive GDP-bound state, enabling it to facilitate the transport of key macromolecules. Research into RAN and its recombinant proteins has gained significance due to their involvement in various cellular processes and their potential implications in diseases, including cancer. The understanding of RAN's mechanism has been further enhanced by advances in structural biology, allowing researchers to elucidate its interactions with different transport receptors and other molecular partners. Recombinant RAN proteins offer valuable tools for in vitro assays, enabling the investigation of its functional properties and regulatory mechanisms. Furthermore, studying RAN and its interactions may lead to the development of novel therapeutic strategies, particularly in targeting nuclear transport pathways that are often dysregulated in diseases. As such, RAN recombinant proteins serve as pivotal components in molecular biology research, providing insights into fundamental cellular functions and their perturbations in pathological states.
