Analytical Data
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基因名
PRKRIR
- Application
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别名
58KDA interferon-induced protein kinase-interacting protein ;p58IPK-interacting proteinDeath-associated protein 4THAP domain-containing protein 0
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43422
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表达区间
612-761aa
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分子量
33.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRKRIR (Protein Kinase, Interferon-Inducible Double-Stranded RNA-Dependent Activator) is a key player in the cellular response to viral infections and the modulation of immune responses. As an interferon-stimulated gene (ISG), PRKRIR is upregulated in response to viral pathogens and plays a crucial role in antiviral defense mechanisms. Its primary function involves the activation of the protein kinase R (PKR) pathway, which is essential for the recognition of viral RNA and the subsequent inhibition of viral replication. The study of PRKRIR encompasses its structural properties, regulatory mechanisms, and functional interactions within the immune system. Researchers are exploring its potential applications in developing antiviral therapies and understanding immune modulation, particularly in the context of chronic viral infections and autoimmune diseases. By enhancing our knowledge of PRKRIR and its signaling pathways, we aim to uncover novel strategies for therapeutic intervention and improve the efficacy of existing treatments in viral infections and immune-related conditions. Additionally, the exploration of PRKRIR may yield insights into the broader interactions of ISGs in immune responses, highlighting the complexity of pathogen-host interactions and the intricate network of cellular signaling involved in maintaining homeostasis during infection. Understanding PRKRIR's multifaceted roles will be pivotal in designing targeted approaches for combating viral diseases and enhancing the immune response in various clinical settings.
