Analytical Data
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Gene name
PERP
- Application
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Alternative Names
Keratinocyte-associated protein 1
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96FX8
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Expression Region
1-193aa
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Molecular Weight
41.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PERP (p53 apoptosis effector related to PMP-22) is a crucial protein involved in various cellular processes, including cell adhesion, migration, and apoptosis, especially in the context of cancer. Discovered as a p53 target gene, it plays a significant role in mediating the tumor suppressor functions of p53 by promoting apoptosis in response to cellular stress. Recent studies have shown that PERP is often downregulated or mutated in various malignancies, leading to impaired apoptotic responses and contributing to tumorigenesis. The characterization of PERP’s structure and function has garnered attention in the cancer research community, as understanding its mechanism could reveal novel therapeutic targets and strategies. The focus on PERP has also expanded into investigating its role in other diseases, including neurodegenerative disorders, where its expression and function may impact neuronal survival. The ongoing research into PERP’s complex pathways and interactions within the cell continues to highlight its potential as a biomarker for cancer prognosis and a target for innovative cancer therapies.
