Analytical Data
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基因名
PERP
- Application
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别名
Keratinocyte-associated protein 1
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96FX8
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表达区间
1-193aa
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分子量
41.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PERP (p53 apoptosis effector related to PMP-22) is a crucial protein involved in various cellular processes, including cell adhesion, migration, and apoptosis, especially in the context of cancer. Discovered as a p53 target gene, it plays a significant role in mediating the tumor suppressor functions of p53 by promoting apoptosis in response to cellular stress. Recent studies have shown that PERP is often downregulated or mutated in various malignancies, leading to impaired apoptotic responses and contributing to tumorigenesis. The characterization of PERP’s structure and function has garnered attention in the cancer research community, as understanding its mechanism could reveal novel therapeutic targets and strategies. The focus on PERP has also expanded into investigating its role in other diseases, including neurodegenerative disorders, where its expression and function may impact neuronal survival. The ongoing research into PERP’s complex pathways and interactions within the cell continues to highlight its potential as a biomarker for cancer prognosis and a target for innovative cancer therapies.
