Analytical Data
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基因名
CNGA4
- Application
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别名
Cyclic nucleotide-gated channel alpha-4 Short name: CNG channel alpha-4 Short name: CNG-4 Short name: CNG4
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IV77
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表达区间
1-575aa
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分子量
82 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CNGA4, a subunit of the cyclic nucleotide-gated (CNG) channels, plays a vital role in the sensory transduction pathways of photoreceptor cells in the retina and olfactory sensory neurons. Mutations in the CNGA4 gene can lead to several inherited retinal diseases, including complete congenital stationary night blindness and other visual impairments. Research on CNGA4 recombinant protein is crucial for understanding the structural and functional characteristics of CNG channels, which are essential for the phototransduction process. By expressing and purifying CNGA4 as a recombinant protein, scientists aim to elucidate the mechanisms governing channel opening and ion selectivity, as well as its interactions with other proteins and signaling molecules. This research has the potential to uncover the pathophysiological mechanisms underlying CNGA4-related disorders and may pave the way for novel therapeutic strategies, including gene therapy and pharmacological interventions. Additionally, studying the recombinant protein can facilitate the development of drugs targeting CNG channels, with applications extending beyond vision science to other physiological systems where these channels are implicated. Overall, the investigation of CNGA4 recombinant protein represents an important frontier in biomedical research, bridging fundamental biology and clinical applications.
