Analytical Data
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Gene name
RFWD2
- Application
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Alternative Names
Constitutive photomorphogenesis protein 1 homolog Short name: hCOP1 RING finger and WD repeat domain protein 2 RING finger protein 200
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NHY2
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Expression Region
1-731aa
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Molecular Weight
84.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RFWD2, also known as Ring Finger Protein 41, is a ubiquitin ligase that plays a crucial role in multiple cellular processes, including DNA damage response, cell cycle regulation, and protein homeostasis. Its ability to add ubiquitin moieties to target proteins marks them for degradation or alters their function, positioning RFWD2 as a key player in maintaining cellular integrity. Recent studies have indicated that RFWD2 is implicated in various diseases, including cancer, where its dysregulation can lead to abnormal cell proliferation and survival. Moreover, RFWD2 has been linked to the modulation of p53, a pivotal tumor suppressor, further emphasizing its potential as a therapeutic target. As research continues to unveil the intricate mechanisms of RFWD2, the recombination and characterization of RFWD2 protein have gained significance, providing insights into its biochemical properties and interactions. Understanding RFWD2 at the molecular level could pave the way for novel strategies in drug development aimed at restoring normal cellular functions in conditions where RFWD2 activity is compromised. Consequently, the study of RFWD2 recombination protein not only enhances our comprehension of fundamental biological processes but also offers promising avenues for therapeutic intervention in diseases associated with its malfunction.
