Analytical Data
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Gene name
Mcu
- Application
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Alternative Names
Mcu; Calcium uniporter protein; mitochondrial
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Species
Mouse
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3UMR5
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Expression Region
50-350aa
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Molecular Weight
37.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on Mcu (Mitochondrial Calcium Uniporter) recombinant proteins has gained significant attention due to its pivotal role in calcium homeostasis within mitochondria, which is crucial for various cellular processes, including energy production, apoptosis, and cell signaling. Disruptions in mitochondrial calcium uptake have been linked to numerous pathological conditions, such as neurodegenerative diseases, cardiovascular disorders, and metabolic syndromes. As Mcu operates as a key regulator of mitochondrial calcium levels, understanding its structure and function through recombinant protein studies can provide insights into its mechanisms and interactions. Furthermore, the production of Mcu recombinant proteins facilitates the investigation of their biophysical properties and pharmacological potential, paving the way for novel therapeutic strategies to target mitochondrial dysfunction. Recent advancements in molecular cloning and expression systems have made it feasible to produce functional Mcu proteins in vitro, allowing researchers to explore their roles in greater detail. This research not only enhances our understanding of mitochondrial dynamics but also opens up possibilities for the development of drugs aimed at modulating calcium signaling pathways in various diseases, thereby underscoring the relevance of Mcu recombinant protein studies in biomedical research.
